Poloniex is an established crypto to crypto exchange that is based in the United States. It offers a large selection of tokens to trade and has high liquidity. Poloniex was hacked in 2014, and lost more than 12% of their bitcoin supply. They have improved their security protocols since then. In February, 2018 Poloniex was acquired by Circle, one of the largest crypto payment providers.

Trading Fee: 0%-0.1% Maker and 0%-0.2% Taker
Deposit Fee: Varying Depending on blockchain fees
Withdrawal Fee: Varying Depending on blockchain fees
Number of Tokens/Coins: 97

OKEx is a relatively new exchange that allows cryptocurrency investors to trade a wide variety of fiat and crytpo pairs. Although it is based in China, and caters to the Chinese market, it has a platform that is easy to use in all languages, and has quickly become one of the largest exchanges, by volume, in the world. The highly secure platform provides high liquidity, and has a number of other advantages.
OKEx has a user friendly interface that can be understood by all traders, regardless of their experience. Their platform is a good option for new crypto users because it supports trading of one of the widest varieties of different cryptocurrencies. It is also a good option for professional investors and day traders. They offer high trading limits, future contracts, and a number of other trading tools, including a block explorer.
Withdrawal Fee: 0.1% with a minimum of $15
Trading Fee: 0.2%

Kraken is a US-based cryptocurrency exchange and one of the largest bitcoin exchanges in terms of volume and liquidity.
It provides Bitcoin pricing to the Bloomberg Terminal and has considerable influence on the overall crypto market. Kraken offers a number fiat funding and transfer options.
There are 18 BTC pairs and 16 USD pair to trade
Fees vary depending on the volume - for main trading pairs this is between 0.1-0.35% - however for other less common crypto pairs the range can be as low as 0.05% or as high as 0.75%. There are also 0% fees for some trades.
Withdrawals and deposits are variable depending on the method - although in general all fees are 0.19% with a $20 minimum.