Poloniex is an established crypto to crypto exchange that is based in the United States. It offers a large selection of tokens to trade and has high liquidity. Poloniex was hacked in 2014, and lost more than 12% of their bitcoin supply. They have improved their security protocols since then. In February, 2018 Poloniex was acquired by Circle, one of the largest crypto payment providers.

Trading Fee: 0%-0.1% Maker and 0%-0.2% Taker
Deposit Fee: Varying Depending on blockchain fees
Withdrawal Fee: Varying Depending on blockchain fees
Number of Tokens/Coins: 97

Simex is an exchange that is focused on the Russian crypto market but is registered in the United States. Simex offers a limited token selection that users can purchase with USD or Rubles. They offer convenient debit card withdrawal options.

Trading Fee: 0.2%
Deposit Fee: Up to 3.3%
Withdrawal Fee: Up to 6%
Number of Tokens/Coins: 6

Simex issued the SMX token, which gives holders discounts on trading.

Gate.io is a crypto to crypto exchange based in the USA. It is an unregulated exchange and does not accept US clients. They offer one of the widest selections of tokens.

Trading Fee: 0.2%
Withdrawal Fee: 0.01 BTC, 0.03 ETH
Number of Tokens/Coins: 347

Gate.io has received many negative reviews regarding difficulties withdrawing funds.