Poloniex is an established crypto to crypto exchange that is based in the United States. It offers a large selection of tokens to trade and has high liquidity. Poloniex was hacked in 2014, and lost more than 12% of their bitcoin supply. They have improved their security protocols since then. In February, 2018 Poloniex was acquired by Circle, one of the largest crypto payment providers.

Trading Fee: 0%-0.1% Maker and 0%-0.2% Taker
Deposit Fee: Varying Depending on blockchain fees
Withdrawal Fee: Varying Depending on blockchain fees
Number of Tokens/Coins: 97

Simex is an exchange that is focused on the Russian crypto market but is registered in the United States. Simex offers a limited token selection that users can purchase with USD or Rubles. They offer convenient debit card withdrawal options.

Trading Fee: 0.2%
Deposit Fee: Up to 3.3%
Withdrawal Fee: Up to 6%
Number of Tokens/Coins: 6

Simex issued the SMX token, which gives holders discounts on trading.

Bittrex is one of the largest crypto to crypto exchanges. It offers a large number of trading pairs, but do not allow fiat to crypto trading. Bittrex has one of the largest trading volumes in the market.
It is a reputable exchange with good record on security and is also fully regulated. They provide two factor authentication as well as a number of other options to secure funds. They are United States based and are fully compliant with all laws.
They support more than 190 cryptocurrencies and have a dynamic platform. It’s a good option for both advanced and beginner traders; providing advanced tools like candlestick charts and crosshairs, but with a user-friendly interface that is very intuitive.
Trading Fees: 0.25%