Bittrex is one of the largest crypto to crypto exchanges. It offers a large number of trading pairs, but do not allow fiat to crypto trading. Bittrex has one of the largest trading volumes in the market.
It is a reputable exchange with good record on security and is also fully regulated. They provide two factor authentication as well as a number of other options to secure funds. They are United States based and are fully compliant with all laws.
They support more than 190 cryptocurrencies and have a dynamic platform. It’s a good option for both advanced and beginner traders; providing advanced tools like candlestick charts and crosshairs, but with a user-friendly interface that is very intuitive.
Trading Fees: 0.25%

QUOINE is a Japanese fintech company that is developing several liquidity focused trading platforms. QUOINE was the first cryptocurrency company to be officially licensed by the Japanese Financial Services Agency.
QUOINE runs 2 exchanges and a platform called LIQUID, that is designed to solve the problems related to liquidity in crypto markets. Quoinex is a fully regulated Crypto-Fiat exchange and was the first exchange to ever be audited by Deloitte. Qryptos is a crypto-only exchange.
The company's exchanges have an attractive fee structure

Trading Fee: 0 for base currency pairs, 0.25% for BTC and BHC pairs, 0.1% for ETH pairs
Withdrawal Fee: $5/5 Euros on fiat currency, Free on Crypto withdrawals
Number of Tokens/Coins: 50

QUOINE's platforms are powered by the QASH utility token.