Bittrex is one of the largest crypto to crypto exchanges. It offers a large number of trading pairs, but do not allow fiat to crypto trading. Bittrex has one of the largest trading volumes in the market.
It is a reputable exchange with good record on security and is also fully regulated. They provide two factor authentication as well as a number of other options to secure funds. They are United States based and are fully compliant with all laws.
They support more than 190 cryptocurrencies and have a dynamic platform. It’s a good option for both advanced and beginner traders; providing advanced tools like candlestick charts and crosshairs, but with a user-friendly interface that is very intuitive.
Trading Fees: 0.25%

Huobi is one of the world's leading trading platform, committed to providing investors with a professional, safe and honest transaction services. The Exchange charges no deposit fees but does have an exit fee of between 1% and 2%. It was originally based in China, but moved its' headquarters to Singapore, and also has offices in Hong Kong, Korea, Japan and the United States.
Huobi has raised capital from investors including Dai Zhikang, Sequoia Capital and Zhen Fund. Huobi is a major player in the Chinese blockchain scene. It runs a mining pool, (Huobi Pool) incubator, (Huobi Labs) and a research institution. (Huobi Academy of Blockchain Applications)
Trading fee of 0.2%