Bittrex is one of the largest crypto to crypto exchanges. It offers a large number of trading pairs, but do not allow fiat to crypto trading. Bittrex has one of the largest trading volumes in the market.
It is a reputable exchange with good record on security and is also fully regulated. They provide two factor authentication as well as a number of other options to secure funds. They are United States based and are fully compliant with all laws.
They support more than 190 cryptocurrencies and have a dynamic platform. It’s a good option for both advanced and beginner traders; providing advanced tools like candlestick charts and crosshairs, but with a user-friendly interface that is very intuitive.
Trading Fees: 0.25%

Bitbank is a regulated fiat to crypto exchange that is based in Japan. It currently does not have any trading fees. Bitbank is one of the largest Japanese cryptocurrency platforms, and ranks in the top 30 exchanges for total trading volume. Bitbank also offers several other crypto services in Japan.

Trading Fee: 0
Withdrawal Fee: 0.001 BTC, 0.001 ETH
Number of Markets: 8

Trade.io is a Switzerland-based financial technology company. Their platform consists of a cryptocurrency exchange and liquidity pool that gives TIOX token holders a share of the revenues that are earned. The company also provides ICO consulting services.