Binance is the largest cryptocurrency exchange by trading volume. The large trading volumes and range of cryptocurrency pairs available for trading, make Binance one of the most influential companies in the blockchain field. The Binance Coin (BNB) gives holders a discount on trading. Binance is capable of processing 1.4 mil orders/second, has multi-language support – Chinese, English, Korean, Japanese and has all the major coins available – BTC, ETH, LTC, BNB etc. Binance's trading fee is 0.1%.

Bittrex is one of the largest crypto to crypto exchanges. It offers a large number of trading pairs, but do not allow fiat to crypto trading. Bittrex has one of the largest trading volumes in the market.
It is a reputable exchange with good record on security and is also fully regulated. They provide two factor authentication as well as a number of other options to secure funds. They are United States based and are fully compliant with all laws.
They support more than 190 cryptocurrencies and have a dynamic platform. It’s a good option for both advanced and beginner traders; providing advanced tools like candlestick charts and crosshairs, but with a user-friendly interface that is very intuitive.
Trading Fees: 0.25%

Gate.io is a crypto to crypto exchange based in the USA. It is an unregulated exchange and does not accept US clients. They offer one of the widest selections of tokens.

Trading Fee: 0.2%
Withdrawal Fee: 0.01 BTC, 0.03 ETH
Number of Tokens/Coins: 347

Gate.io has received many negative reviews regarding difficulties withdrawing funds.