Truffle is one of the leading providers of blockchain development tools. The Truffle platform consists of three tools that are designed to assist developers in creating DApps: Truffle, Ganache and Drizzle. Truffle is a testing framework for DApps using the Etereum Virtual Machine. Ganache allows users to easily create a personalized version of the Ethereum blockchain to run tests and execute commands. Drizzle is a collection of front-end libraries that help developers create user interfaces for DApps.

FLO is a Proof-of-Work blockchain with a metadata layer called floData. It enables users to easily record notes to its blocks, and can be used to create DApps. One of FLO's central features is the Open Index Protocol, which standardizes cryptographic ownership on open networks. The founders of FLO are also working on Alexandria; an open-source standard for users to publish and distribute original content. FLO's source code is based on that of Bitcoin and Litecoin. It is designed to enable fast transactions times.

NEO, formerly known as AntShares, is one of the leading smart contract enabled blockchain platforms that allows for the development of digital assets. Similar to Ethereum, NEO uses two different tokens: NEO and GAS, each of which have a specific purpose on the network. NEO tokens give holders a share in the ownership of the NEO blockchain, and when they are held in a compatible wallet, they are rewarded with GAS tokens. NEO has a Delegated Byzantine Fault Tolerance (dBFT) consensus algorithm that has uses some features of PoS, and is designed to be more scalable than other consensus mechanisms.