FLO is a Proof-of-Work blockchain with a metadata layer called floData. It enables users to easily record notes to its blocks, and can be used to create DApps. One of FLO's central features is the Open Index Protocol, which standardizes cryptographic ownership on open networks. The founders of FLO are also working on Alexandria; an open-source standard for users to publish and distribute original content. FLO's source code is based on that of Bitcoin and Litecoin. It is designed to enable fast transactions times.

Skycoin began as an ambitious infrastructure project aimed at replacing the Proof-of-Work (PoW) and Proof-of-Stake (PoS) consensus algorithms that dominate current blockchain platforms. It has since evolved into a project focused on creating a decentralized mesh-Internet and a platform for other blockchain-based projects. Skycoin is developing an ecosystem with a variety of goals, including: the elimination of mining rewards, development of energy-efficient custom hardware, advancing security and privacy, and achieving transaction speeds that rival current digital payment systems. The ecosystem consists of the native SKY coin, Skywire (decentralized mesh-Internet), Skyminer (hardware and access point for Skywire), Skyledger (decentralized open blockchain network), and a suite of DApps. The consensus algorithm is called Obelisk. The network's nodes agree based on a Web-of-Trust consensus. The ability to influence transaction verification is distributed over the network creating a web of trust. To eliminate mining completely each node on the network connects to a list of nodes that it sees as trustworthy.

NEO, formerly known as AntShares, is one of the leading smart contract enabled blockchain platforms that allows for the development of digital assets. Similar to Ethereum, NEO uses two different tokens: NEO and GAS, each of which have a specific purpose on the network. NEO tokens give holders a share in the ownership of the NEO blockchain, and when they are held in a compatible wallet, they are rewarded with GAS tokens. NEO has a Delegated Byzantine Fault Tolerance (dBFT) consensus algorithm that has uses some features of PoS, and is designed to be more scalable than other consensus mechanisms.