FLO is a Proof-of-Work blockchain with a metadata layer called floData. It enables users to easily record notes to its blocks, and can be used to create DApps. One of FLO's central features is the Open Index Protocol, which standardizes cryptographic ownership on open networks. The founders of FLO are also working on Alexandria; an open-source standard for users to publish and distribute original content. FLO's source code is based on that of Bitcoin and Litecoin. It is designed to enable fast transactions times.

Nethereum is an open source .NET integration library for Ethereum. It is designed to help developers easily integrate the Ethereum blockchain into their .NET applications. It consists of modular libraries for features that are covered are writing smart contracts, cryptographic wallets, DApps, and managing blockchain data.

QuarkChain is building a blockchain with a focus on speed and scalability. They hope to significantly improve transaction times and reduce fees with an architecture that will rely on a two-layered blockchain and elastic sharding. QuarkChain uses a hybrid Proof-of-Work (PoW) consensus mechanism that is ASIC-resistant. Transactions are first confirmed on one blockchain layer, and then on the second. The network will be powered by the QKC coin.