FLO is a Proof-of-Work blockchain with a metadata layer called floData. It enables users to easily record notes to its blocks, and can be used to create DApps. One of FLO's central features is the Open Index Protocol, which standardizes cryptographic ownership on open networks. The founders of FLO are also working on Alexandria; an open-source standard for users to publish and distribute original content. FLO's source code is based on that of Bitcoin and Litecoin. It is designed to enable fast transactions times.

Blockstream is a private, for profit, blockchain technology company, that has played a key role in helping to develop, and fund, many of the key features of the Bitcoin Core platform. Blockstream is focused on developing bitcoin applications and has raised significant funding from several large investment funds. The company also employs several developers that are very influential within the Bitcoin Core development project. This, as well as being of Bitcoin's largest donors, has led to some criticism about conflicts of interest.
Blockstream is developing a number of Bitcoin applications that are intended to encourage adoption and improve transaction times on the bitcoin network. Their primary focus is on Sidechains, which are are extensions to existing blockchains that improve their functionality. The company is also working closely with industry leaders to create the Bitcoin Lightning system that will support higher trading volume and faster transactions on the bitcoin network. Blockstream is also developing a data feed, satellite network, and other applications that they hope will make blockchain more accessible.

Bytecent is developing a decentralized rewards network powered by blockchain. Bytecent allows merchants to create customer loyalty programs that are cross-site and cross-platform compatible. Consumers are not restricted to using their rewards with just one merchant, and can redeem them anywhere Bytecent is accepted. In addition to secure transactions and portability, Bytecent never expire and there are no limitations on how many Bytecent you can accumulate or spend. BYC can be converted to Bitcoin, cash, and gift cards. Bytecent uses a variation of Proof-of-Work (PoW) for consensus that requires miners to manually attend to their computers and is called Proof-of-Miner (PoM). It's designed to prevent the use of advanced and autonomous mining hardware. Avanquest Software, a leading developer of consumer software, has implemented Bytecent for their rewards program.