ConsenSys is one of the most influential blockchain technology companies. They are working on a variety of projects to create the infrastructure and applications that will enable scalable adoption of blockchain-based systems. The company's efforts are focused on the Ethereum ecosystem, and include divisions working to advance technology development, establish industry standards, and provide consulting, marketing, and education services.

Harmony is developing an open consensus blockchain platform. Harmony's sharding-based consensus mechanism is designed to scale as the number of nodes increases in the network. Harmony aims to tackle issues related to scalability by optimizing across multiple layers in a way that will enable parallel transaction processing with reduced latency. Harmony is currently powered by the ONE token, which is built on the Binance blockchain.

Skycoin began as an ambitious infrastructure project aimed at replacing the Proof-of-Work (PoW) and Proof-of-Stake (PoS) consensus algorithms that dominate current blockchain platforms. It has since evolved into a project focused on creating a decentralized mesh-Internet and a platform for other blockchain-based projects. Skycoin is developing an ecosystem with a variety of goals, including: the elimination of mining rewards, development of energy-efficient custom hardware, advancing security and privacy, and achieving transaction speeds that rival current digital payment systems. The ecosystem consists of the native SKY coin, Skywire (decentralized mesh-Internet), Skyminer (hardware and access point for Skywire), Skyledger (decentralized open blockchain network), and a suite of DApps. The consensus algorithm is called Obelisk. The network's nodes agree based on a Web-of-Trust consensus. The ability to influence transaction verification is distributed over the network creating a web of trust. To eliminate mining completely each node on the network connects to a list of nodes that it sees as trustworthy.