ConsenSys is one of the most influential blockchain technology companies. They are working on a variety of projects to create the infrastructure and applications that will enable scalable adoption of blockchain-based systems. The company's efforts are focused on the Ethereum ecosystem, and include divisions working to advance technology development, establish industry standards, and provide consulting, marketing, and education services.

APEX is building a blockchain infrastructure for consumer applications that will focus on B2C transactions on the internet. Their goal is to provide an enterprise blockchain solution for creating custom DApps that will be used by consumers. The NEO-based network was created by APEX Technologies (formerly Chinapex), an established data technology and AI company. Their network is powered by the NEO-based CPX token.

FLO is a Proof-of-Work blockchain with a metadata layer called floData. It enables users to easily record notes to its blocks, and can be used to create DApps. One of FLO's central features is the Open Index Protocol, which standardizes cryptographic ownership on open networks. The founders of FLO are also working on Alexandria; an open-source standard for users to publish and distribute original content. FLO's source code is based on that of Bitcoin and Litecoin. It is designed to enable fast transactions times.