ConsenSys is one of the most influential blockchain technology companies. They are working on a variety of projects to create the infrastructure and applications that will enable scalable adoption of blockchain-based systems. The company's efforts are focused on the Ethereum ecosystem, and include divisions working to advance technology development, establish industry standards, and provide consulting, marketing, and education services.

APEX is building a blockchain infrastructure for consumer applications that will focus on B2C transactions on the internet. Their goal is to provide an enterprise blockchain solution for creating custom DApps that will be used by consumers. The NEO-based network was created by APEX Technologies (formerly Chinapex), an established data technology and AI company. Their network is powered by the NEO-based CPX token.

Blockstream is a private, for profit, blockchain technology company, that has played a key role in helping to develop, and fund, many of the key features of the Bitcoin Core platform. Blockstream is focused on developing bitcoin applications and has raised significant funding from several large investment funds. The company also employs several developers that are very influential within the Bitcoin Core development project. This, as well as being of Bitcoin's largest donors, has led to some criticism about conflicts of interest.
Blockstream is developing a number of Bitcoin applications that are intended to encourage adoption and improve transaction times on the bitcoin network. Their primary focus is on Sidechains, which are are extensions to existing blockchains that improve their functionality. The company is also working closely with industry leaders to create the Bitcoin Lightning system that will support higher trading volume and faster transactions on the bitcoin network. Blockstream is also developing a data feed, satellite network, and other applications that they hope will make blockchain more accessible.