Chain is a blockchain software company that creates blockchain-based systems for financial institutions and major companies. They've developed blockchain solutions for companies like Nasdaq, Visa, and Citigroup, as well as a variety of crytpocurrencies. Chain has been successful in incorporating distributed ledger technology in very large and influential companies. Their focus is on using the core innovations of blockchain to improve existing systems. Chain uses blockchain as a software tool that can be applied where it is important for services or product to have more trust, or to build a network without an intermediary

CanonChain is developing an underlying blockchain protocol based on Fog networking and a Proof-of-Participation (PoP) consensus mechanism. Their network is designed to provide incentives for contributing computing resources on fragmented networks, and is powered by the Ethereum-based CZR token, known as Xuanchi.

Nethereum is an open source .NET integration library for Ethereum. It is designed to help developers easily integrate the Ethereum blockchain into their .NET applications. It consists of modular libraries for features that are covered are writing smart contracts, cryptographic wallets, DApps, and managing blockchain data.