APEX is building a blockchain infrastructure for consumer applications that will focus on B2C transactions on the internet. Their goal is to provide an enterprise blockchain solution for creating custom DApps that will be used by consumers. The NEO-based network was created by APEX Technologies (formerly Chinapex), an established data technology and AI company. Their network is powered by the NEO-based CPX token.

Blockstream is a private, for profit, blockchain technology company, that has played a key role in helping to develop, and fund, many of the key features of the Bitcoin Core platform. Blockstream is focused on developing bitcoin applications and has raised significant funding from several large investment funds. The company also employs several developers that are very influential within the Bitcoin Core development project. This, as well as being of Bitcoin's largest donors, has led to some criticism about conflicts of interest.
Blockstream is developing a number of Bitcoin applications that are intended to encourage adoption and improve transaction times on the bitcoin network. Their primary focus is on Sidechains, which are are extensions to existing blockchains that improve their functionality. The company is also working closely with industry leaders to create the Bitcoin Lightning system that will support higher trading volume and faster transactions on the bitcoin network. Blockstream is also developing a data feed, satellite network, and other applications that they hope will make blockchain more accessible.

ProximaX is developing a NEM-based platform with several on-chain and off-chain protocols. At its core, ProximaX is based on the NEM blockchain, and is designed to be an all-in-one platform for developing DApps. The platform has several parallel layers that are intended to provide decentralized storage, messaging, streaming, and content delivery services. The network is powered by the NEM-based XPX token. ProximaX intends on using a hybrid consensus mechanism for validating value transfers on these layers. Consensus will be driven with a combination of Proof-of-Importance (PoI), Proof-of-Storage (PoSt), and Proof-of-Bandwidth (PoB).