Primecoin is a cryptocurrency based on finding prime numbers. Identifying prime numbers plays a central role in cryptography. Primecoin's unique Proof-of-Work (PoW) consensus mechanism is able to increase transaction speeds and improve energy efficiency.
The network searches for special prime number chains known as Cunningham chains and bi-twin chains, which are of interest in mathematical research.

Sphere is a smart contract platform and peer-to-peer payment network. The network has a hybrid PoW and PoS consensus mechanism and is powered by the native SPHR token, which can be swapped for an ERC20 token over the Ubiq smart contract platform.

Qtum has been described as a hybrid between Ethereum and Bitcoin. Qtum is a smart contracts platform that places a strong focus on value transfers as well as decentralized apps. Qtum enables users to create smart contracts on the platform and conduct cryptocurrency transactions.
Qtum has a Proof-of-Stake (PoS) consensus algorithm. Several decentralized apps are already using the platform.