Primecoin is a cryptocurrency based on finding prime numbers. Identifying prime numbers plays a central role in cryptography. Primecoin's unique Proof-of-Work (PoW) consensus mechanism is able to increase transaction speeds and improve energy efficiency.
The network searches for special prime number chains known as Cunningham chains and bi-twin chains, which are of interest in mathematical research.

Qtum has been described as a hybrid between Ethereum and Bitcoin. Qtum is a smart contracts platform that places a strong focus on value transfers as well as decentralized apps. Qtum enables users to create smart contracts on the platform and conduct cryptocurrency transactions.
Qtum has a Proof-of-Stake (PoS) consensus algorithm. Several decentralized apps are already using the platform.

Vitae is a Proof-of-Stake (PoS) blockchain platform that is a fork of PIVx. It is based on Blackcoin's PoS protocol. The company's marketing materials claim that its focus will be on facilitating social rewards and global prosperity, but they do not provide any specifics about what will distinguish them from other networks. It is powered by the VITAE coin.